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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Epitope peptides and immunotherapy.

Soichi Tanabe1

  • 1Hiroshima University, 1-4-4, Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8528, Japan. stanabe@hiroshima-u.ac.jp

Current Protein & Peptide Science
|February 20, 2007
PubMed
Summary

Understanding allergen epitopes is key to developing new allergy treatments. This research explores modifying T cell epitopes for effective immunotherapy, including a novel approach of

Area of Science:

  • Immunology
  • Allergy Research
  • Molecular Biology

Background:

  • Allergic diseases are mediated by specific Immunoglobulins E (IgE) binding to allergen epitopes.
  • Identifying these IgE-binding sites (B cell epitopes) is crucial for understanding allergy.
  • Allergen-specific T cells are also critical targets for therapeutic intervention.

Purpose of the Study:

  • To provide an overview of epitopes in allergic diseases.
  • To focus on allergen-specific immunotherapy strategies.
  • To describe a novel approach of immunotherapy using T cell epitope peptides.

Main Methods:

  • Analysis of IgE-binding B cell epitopes.
  • Modification of B cell epitopes to prevent IgE binding while preserving T cell epitopes.

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  • Administration of T cell epitope peptides for immunotherapy.

    • Main Results:

    • B cell epitope structures have been clarified, with as few as 4-5 amino acids being sufficient for IgE binding.
    • T cell epitope-based immunotherapy has shown promise in clinical studies.
    • A new strategy involves 'eating' T cell epitope peptides for tolerance induction.

    Conclusions:

    • Epitope identification advances allergy etiology understanding and treatment development.
    • T cell epitope immunotherapy offers a viable strategy for allergy treatment.
    • Oral administration of T cell epitope peptides presents a practical approach to allergy prevention and tolerance induction.