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Updated: Jul 16, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Risk factors for first trimester miscarriage--results from a UK-population-based case-control study
N Maconochie1, P Doyle, S Prior
1Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, UK. noreen.maconochie@lshtm.ac.uk
BJOG : an International Journal of Obstetrics and Gynaecology
|February 20, 2007
Summary
This study identified key risk factors for first trimester miscarriage, including high maternal age, stress, and previous terminations. Promoting a healthy lifestyle and emotional wellbeing may help reduce miscarriage risk.
Area of Science:
- Reproductive Health
- Epidemiology
- Obstetrics
Background:
- Miscarriage is a common pregnancy complication.
- Understanding risk factors is crucial for prevention and early intervention.
- Previous research has explored various factors, but a comprehensive analysis is needed.
Purpose of the Study:
- To investigate the association between biological, behavioral, and lifestyle factors and the risk of first-trimester miscarriage.
- To identify modifiable and non-modifiable risk factors for miscarriage.
Main Methods:
- Population-based case-control study.
- Involved 603 women with first-trimester miscarriage and 6116 controls (pregnancy >12 weeks).
- Data collected via postal survey on socio-demographic, behavioral, and lifestyle factors.
Main Results:
- Increased miscarriage risk associated with high maternal age, previous miscarriage/termination/infertility, assisted conception, low BMI, high alcohol intake, and stress.
- Reduced risk observed with previous live birth, nausea, vitamin supplementation, fruit/vegetable intake, and feeling well.
- No significant association found with caffeine, smoking, moderate alcohol, education, socio-economic status, or working during pregnancy after adjustments.
Conclusions:
- Advice on healthy diet, stress reduction, and emotional wellbeing may lower miscarriage risk.
- Factors like previous termination, stress, partner change, and low pre-pregnancy weight warrant further investigation.
- Findings highlight the importance of a holistic approach to early pregnancy care.
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