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Related Experiment Video

Updated: Jul 16, 2026

Robotic Duodenal Sleeve Resection for Gastrointestinal Stromal Tumor with Rare Exon 8 KIT Mutation Following Neoadjuvant Imatinib
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Multiple rectal carcinoids with diffuse ganglioneuromatosis.

Masashi Haraguchi1, Hideki Kinoshita, Miho Koori

  • 1Department of Surgery, Goto Central Hospital, Nagasaki, Japan. haraguci@mb.ejnet.ne.jp

World Journal of Surgical Oncology
|February 20, 2007
PubMed
Summary

This case study highlights a rare instance of multiple rectal carcinoid tumors with diffuse ganglioneuromatosis. Individualized treatment and careful follow-up are crucial for managing this unusual rectal neoplasm.

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Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Pathology

Background:

  • Rectal carcinoids are rare anorectal neoplasms, accounting for approximately 1% of all such tumors.
  • Gastrointestinal ganglioneuroma is an uncommon tumor characterized by ganglion cells, nerve fibers, and supporting cells.
  • The co-occurrence of multiple rectal carcinoids and diffuse rectal ganglioneuromatosis is exceptionally rare.

Observation:

  • A 69-year-old male presented with approximately 100 small, submucosal rectal tumors.
  • The patient underwent an abdominoperineal resection for the condition.
  • Pathological examination confirmed the presence of carcinoid tumors in about 30 submucosal nodules and diffuse ganglioneuromatosis.

Findings:

  • The patient remained disease-free with no recurrence six months post-surgery.

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  • The case demonstrates a unique presentation of multiple rectal carcinoids and ganglioneuromatosis.

    • Implications:

    • Optimal treatment for multiple rectal carcinoids is not definitively established.
    • Radical surgery may not be necessary for all patients with multiple rectal carcinoids under 1 cm.
    • Individualized treatment strategies and diligent follow-up are essential for managing this rare condition.