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Updated: Jul 16, 2026

An Epithelial Abrasion Model for Studying Corneal Wound Healing
Published on: December 29, 2021
[Injury and epithelial wound healing: a pathophysiologic hypothesis for nasal and sinus polyposis]
Diane S Lazard1, Virginie Prulière-Escabasse, Jean-François Papon
1Unité Inserm U651, Créteil, Service ORL et chirurgie cervicofaciale, Hôpital Foch, Suresnes. dianelazard@yahoo.fr
Abstract:
Nasal polyposis (NP), asthma, and chronic bronchitis are chronic inflammatory diseases of the upper airways. They may be caused by injury to the respiratory epithelium in a chronic inflammatory environment. Several studies show that during NP nasal epithelial cells are involved in the overexpression of cytokines and growth factors. Among these, transforming growth factor beta1 (TGF-beta1) appears to play a major role in the genesis of NP. Differentiated respiratory epithelium, obtained from in vivo or in vitro models, is used to study wound healing in inflammatory environments, to elucidate the pathophysiology of NP, and to improve understanding and management of upper airway inflammatory diseases.
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