Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An improved saddlepoint approximation.

Colin S Gillespie1, Eric Renshaw

  • 1School of Mathematics and Statistics, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK.

Mathematical Biosciences
|February 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SBML Level 3: an extensible format for the exchange and reuse of biological models.

Molecular systems biology·2020
Same author

Chronic, Active Inflammation in Patients With Failed Total Knee Replacements Undergoing Revision Surgery.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2019
Same author

Guided proposals for efficient weighted stochastic simulation.

The Journal of chemical physics·2019
Same author

B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome.

Rheumatology (Oxford, England)·2018
Same author

Growth rate control of flagellar assembly in Escherichia coli strain RP437.

Scientific reports·2017
Same author

Profiling inflammation and tissue injury markers in perfusate and bronchoalveolar lavage fluid during human ex vivo lung perfusion.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2017
Same journal

The hydra and hormetic effects in a single discrete-time overcompensation model.

Mathematical biosciences·2026
Same journal

Seasonal impacts on brucellosis transmission mediated by live sheep supply-demand dynamics.

Mathematical biosciences·2026
Same journal

Optimal controls and cost-effectiveness analysis on the transmission dynamics of early blight disease in tomatoes.

Mathematical biosciences·2026
Same journal

Temperature-dependent dynamics and allee effect thresholds mediate fourfold cusp stability in biological control of invasive vectors.

Mathematical biosciences·2026
Same journal

Dynamics of a stochastic tumor-immune interaction system with an Ornstein-Uhlenbeck process.

Mathematical biosciences·2026
Same journal

Post-peak dynamics and epidemic overshoot in SIR-type frameworks.

Mathematical biosciences·2026
See all related articles

The saddlepoint approximation is a key method for probability distributions but has limitations. This study introduces novel techniques to improve its accuracy and support, enhancing its reliability for statistical analysis.

Area of Science:

  • Statistics
  • Computational Statistics

Background:

  • The saddlepoint approximation is the primary 'family-free' method for constructing probability distributions from higher-order moments.
  • It utilizes the efficient steepest descents numerical method but can fail to yield full support.
  • Existing scaling approaches may introduce inaccuracies.

Purpose of the Study:

  • To address the limitations of the saddlepoint approximation, specifically the lack of full support and potential inaccuracies.
  • To propose and evaluate new methods for improving the construction of probability distributions using saddlepoint approximations.

Main Methods:

  • Extending the inversion of the cumulant generating function to second-order.
  • Selecting appropriate probability structures for higher-order cumulants, moving beyond the standard moment closure.

Related Experiment Videos

  • Implementing subtle modifications to target cumulants and optimizing using the simplex algorithm.
  • Main Results:

    • The proposed methods aim to overcome the full support problem associated with saddlepoint approximations.
    • New techniques are introduced to enhance the accuracy and reliability of probability distributions derived from moments.
    • The study explores advanced statistical modeling by refining cumulant-based approaches.

    Conclusions:

    • The developed techniques offer improved solutions for constructing probability distributions using saddlepoint approximations.
    • These advancements enhance the applicability and robustness of statistical inference in situations involving higher-order moments.
    • The research contributes novel methodologies to computational statistics and probability theory.