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Related Experiment Video

Updated: Jul 16, 2026

The TD Drive: A Parametric, Open-Source Implant for Multi-Area Electrophysiological Recordings in Behaving and Sleeping Rats
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The TD Drive: A Parametric, Open-Source Implant for Multi-Area Electrophysiological Recordings in Behaving and Sleeping Rats

Published on: April 26, 2024

A split microdrive for simultaneous multi-electrode recordings from two brain areas in awake small animals.

Carien S Lansink1, Mattijs Bakker, Wietze Buster

  • 1Center for Neuroscience, Swammerdam Institute for Life Sciences, Faculty of Science, Universiteit van Amsterdam, P.O. Box 94084, Kruislaan 320, 1090 GB Amsterdam, The Netherlands.

Journal of Neuroscience Methods
|February 20, 2007
PubMed
Summary

Researchers developed a novel "split drive" enabling simultaneous neural recordings in multiple brain areas. This tool facilitates studying brain communication critical for memory and decision-making in freely moving rats.

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Related Experiment Videos

Last Updated: Jul 16, 2026

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Published on: April 26, 2024

Hybrid Microdrive System with Recoverable Opto-Silicon Probe and Tetrode for Dual-Site High Density Recording in Freely Moving Mice
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Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat
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Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat

Published on: April 2, 2018

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Neural Engineering

Background:

  • Complex cognitive functions involve interconnected brain regions, not isolated areas.
  • Understanding neural communication between brain structures is crucial for cognitive neuroscience.
  • Existing technologies may limit simultaneous recordings in distant brain areas.

Purpose of the Study:

  • To develop and validate a multi-electrode microdrive for simultaneous chronic neural recordings in two distinct brain regions.
  • To enable the study of neural communication between connected brain structures like the hippocampus and ventral striatum.
  • To provide a tool for investigating the neural basis of complex cognitive behaviors.

Main Methods:

  • Design and assembly of a novel "split drive" with 14 independently movable microdrivers for tetrodes.
  • Chronic implantation in rats, allowing day-to-day adjustment of electrode position.
  • Simultaneous ensemble recordings from the hippocampus and ventral striatum during a reward-searching task.

Main Results:

  • The split drive allowed stable, long-term recordings (weeks) in freely moving rats.
  • Successful simultaneous recordings were achieved in the hippocampus and ventral striatum.
  • Ensemble sizes of approximately 15 units in the dorsal hippocampus and 25 units in the ventral striatum were recorded.

Conclusions:

  • The split drive is a viable tool for studying neural communication between widely separated brain areas.
  • This technology facilitates research into the neural circuits underlying memory and decision-making.
  • The system supports stable, long-term ensemble recordings in behaving animals.