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Related Experiment Videos

The sensorimotor slice.

Mary M Rocco1, Joshua C Brumberg

  • 1Neuropsychology Ph.D. Subprogram (Psychology), The Graduate Center, CUNY, 365 5th Avenue, New York, NY 10016, USA.

Journal of Neuroscience Methods
|February 20, 2007
PubMed
Summary
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Reciprocal connections between the primary motor cortex (M1) and somatosensory cortex (S1) are crucial for updating motor plans. Researchers developed a novel sensorimotor slice preparation to study these connections.

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Cortical Connectivity

Background:

  • Reciprocal connections between primary motor cortex (M1) and primary somatosensory cortex (S1) are hypothesized to be vital for motor plan adjustments based on sensory feedback.
  • These interactions enable the sensory cortex to anticipate motor commands.
  • Both M1 and S1 in the mouse neocortex contain representations of the body surface, specifically the whisker representation.

Purpose of the Study:

  • To characterize the axonal pathways connecting the whisker representation of M1 (wM1) and S1 (wS1).
  • To establish a novel brain slice preparation that preserves the sensorimotor pathway between wM1 and wS1 for physiological study.

Main Methods:

  • Physiologically targeted microinjections of biotinylated dextran amine into wM1 or wS1 to trace axonal projections.

Related Experiment Videos

  • Determination of a specific plane of section to include both wM1 and wS1 while maintaining the connecting axonal pathway.
  • In vitro electrophysiological recordings to confirm the maintenance of excitatory synaptic connections within the novel slice preparation.

    • Main Results:

    • Detailed characterization of the axonal pathways connecting wM1 and wS1.
    • Successful development of a novel sensorimotor slice preparation containing both wM1 and wS1.
    • Demonstration that excitatory synaptic connections are preserved in this new slice preparation.

    Conclusions:

    • The developed sensorimotor slice is an effective preparation for studying inter-areal cortical connectivity between M1 and S1.
    • This preparation will facilitate future research into the functional roles of M1-S1 interactions in sensorimotor processing.