Related Experiment Video
Updated: Jul 16, 2026

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
Published on: May 23, 2017
[Nerve fibre bundle defects in a pre-chiasmal lesion]
I Mildenberger1, W Lagrèze, U Schiefer
1Abt. für Pathophysiologie des Sehens und Neuroophthalmologie, Universitäts-Augenklinik Tübingen, Schleichstrasse 12-16, 72076 Tübingen. Ingrid.Mildenberger@med.uni-tuebingen.de
Background:
Prechiasmal lesions of the visual pathway are produced by visual field defects that either affect only one eye or, if both eyes are affected, they are clearly different. Typically, the defects respect the vertical meridian. This report of a case shows that the classical nerve fibre bundle defect must be taken into consideration for differential diagnosis.
Case Report:
In a 67-year-old patient, a meningeoma of the sphenoid was diagnosed that had spread into the optic canal. Examination of the visual field showed an inferior altitudinal nerve fibre bundle defect.
Conclusions:
Apparently the retinal pattern of nerve fibres remains intact even when approaching the optic chiasm. Nerve fibre bundle defects are therefore sometimes found in prechiasmal lesions and should be considered for differential diagnosis (e. g., in the case of a suspected low tension glaucoma).
Related Concept Videos
Neurogenesis and Regeneration of Nervous Tissue
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Nervous Tissue: Myelin
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Secondary Spinal Cord Injury llI: Pathophysiology
