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Management of acute asthma in children using metered dose inhaler and small volume nebulizer

Syed Waseem Jamalvi1, Syed Jamal Raza, Farah Naz

  • 1Department of Pediatrics, Jinnah Medical and Dental College, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|February 23, 2007
PubMed

Insights

Metered dose inhalers with accessory devices (MDI/AD) are as effective as small volume nebulizers (SVN) for treating acute asthma in children. This study found no significant difference in outcomes between the two delivery methods for beta2-agonist medication.

Area of Science:

  • Pediatric Emergency Medicine
  • Respiratory Medicine
  • Pharmacology

Background:

  • Acute asthma exacerbations are common in children.
  • Nebulizers have traditionally been used for delivering beta2-agonists in acute asthma.
  • Alternative delivery methods are being explored for efficacy and accessibility.

Purpose of the Study:

  • To compare the effectiveness of beta2-agonist administration via Metered Dose Inhaler with Accessory Device (MDI/AD) versus Small Volume Nebulizer (SVN).
  • To evaluate treatment outcomes in children with acute asthma exacerbation receiving beta2-agonist therapy.

Main Methods:

  • A cross-sectional study involving 150 children (≥6 months) with acute asthma exacerbation in an Emergency Room.
  • Children were randomized to receive salbutamol via MDI/AD (Group A) or SVN (Group B).
  • Clinical variables and Peak Expiratory Flow Rate (PEFR) were assessed pre- and post-treatment.

Main Results:

  • No significant differences were observed in demographic characteristics or outcome measures between the MDI/AD and SVN groups.
  • PEFR showed significant improvement in both groups post-treatment.
  • Comparative analysis of PEFR between groups did not yield statistically significant differences.

Conclusions:

  • MDI/AD administration of beta2-agonists is an effective alternative to SVN for treating acute asthma exacerbations in pediatric emergency settings.
  • This finding supports the use of MDI/AD for efficient and comparable asthma management in children.
Abstract

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