Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Community-associated methicillin-resistant Staphylococcus aureus sepsis presenting with encephalopathy-like symptoms in a previously healthy young adult].

Rinsho shinkeigaku = Clinical neurology·2026
Same author

USP40 protects podocytes by deubiquitylating integrin β1.

Biochemical and biophysical research communications·2026
Same author

Transcranial Calcium Macro-Imaging From the Auditory Cortex of Thy1-Cre-Driven GCaMP8 Transgenic Rats.

Neuropsychopharmacology reports·2026
Same author

Temporally Coordinated Activity among Motor Cortex, Thalamus, and Thalamic Reticular Nucleus Neurons during Rat Forelimb Movements.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Open-source modular field-programmable gate array system for two-photon mesoscope enabling multiarea, multidepth neural activity recording and lifetime imaging.

Neurophotonics·2026
Same author

Targeting of specific neuronal types in the non-human primate brain by using a murine CD25-specific recombinant immunotoxin.

Scientific reports·2026

Related Experiment Video

Updated: Jul 16, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Controlled cell targeting system to study the brain neural circuitry.

Kazuto Kobayashi1

  • 1Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan. kazuto@fmu.ac.jp

Neuroscience Research
|February 23, 2007
PubMed
Summary

Immunotoxin cell targeting precisely eliminates cells in neural circuits. This technology aids understanding brain functions, particularly dopamine

More Related Videos

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques
06:21

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Published on: May 7, 2020

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
10:58

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

Published on: September 27, 2020

Related Experiment Videos

Last Updated: Jul 16, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques
06:21

Adaptable Angled Stereotactic Approach for Versatile Neuroscience Techniques

Published on: May 7, 2020

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
10:58

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

Published on: September 27, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Understanding neural mechanisms requires precise manipulation of specific cell types within complex brain circuits.
  • Immunotoxin cell targeting offers a transgenic approach to selectively eliminate cells using recombinant immunotoxins.

Purpose of the Study:

  • To review recent applications of immunotoxin cell targeting in neuroscience research.
  • To explore the role of basal ganglia circuitry in motor behavior and dopamine transmission.
  • To propose a model for how dopamine coordinates motor behavior via basal ganglia pathways.

Main Methods:

  • Utilizing transgenic technology for targeted cell elimination.
  • Employing recombinant immunotoxins for their cytotoxic activity.
  • Analyzing basal ganglia circuitry involved in motor control.

Main Results:

  • Demonstrated the utility of immunotoxin cell targeting for studying neural mechanisms.
  • Highlighted recent advancements in applying this technology to basal ganglia research.
  • Presented a novel model for dopamine's role in coordinating motor behavior.

Conclusions:

  • Immunotoxin cell targeting is a valuable tool for dissecting neural circuitry and brain function.
  • The basal ganglia and dopamine pathways are critical for motor behavior coordination.
  • Further research can refine the proposed model of dopamine-mediated motor control.