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Related Experiment Videos

Gating information by two-state membrane potential fluctuations.

A Kepecs1, S Raghavachari

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. kepecs@cshl.edu

Journal of Neurophysiology
|February 23, 2007
PubMed
Summary
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NMDA receptors can induce two-state voltage fluctuations in neurons. This mechanism allows NMDA-rich pathways to gate AMPA-rich inputs, controlling neuronal signaling and gain modulation.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Neurons exhibit two-state voltage fluctuations (up-state and down-state) across brain regions.
  • Synaptic plasticity and neuronal excitability are influenced by receptor dynamics.

Purpose of the Study:

  • To investigate the role of N-methyl-D-aspartate (NMDA) receptors in generating two-state neuronal voltage fluctuations.
  • To elucidate the computational implications of NMDA receptor-mediated gating and gain modulation.

Main Methods:

  • Utilized a biophysical model of neuronal activity.
  • Simulated neuronal responses to distinct AMPA/NMDA receptor-rich inputs.

Main Results:

  • NMDA receptor activity can drive transitions between neuronal up-states and down-states.

Related Experiment Videos

  • NMDA-rich pathways gate AMPA-rich inputs in an all-or-none manner.
  • NMDA-rich pathways multiplicatively enhance neuronal gain in the up-state.

    • Conclusions:

    • NMDA receptor-mediated mechanisms explain ubiquitous two-state neuronal fluctuations.
    • These mechanisms support computations like input gating and gain modulation for signal routing in neural circuits.