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Updated: Jul 16, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
HBV- and HCV- infected workers in the Japanese workplace
Rie Narai1, Tsunehiro Oyama, Masanori Ogawa
1Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan.
Insights
Hepatitis B (HBV) and C (HCV) infected workers often face workplace challenges. While hazardous work rates are similar to the general population, many experience hepatitis exacerbations, with concerns about work-related causes.
Area of Science:
- Occupational Health
- Hepatology
- Public Health
Background:
- Approximately 3 million Japanese individuals have persistent Hepatitis B (HBV) or C (HCV) infections.
- Limited understanding exists regarding the workplace conditions for these infected workers.
Purpose of the Study:
- To investigate the workplace conditions and experiences of workers with HBV or HCV infections.
- To identify factors contributing to hepatitis exacerbation in the workplace.
Main Methods:
- Conducted three types of questionnaire surveys involving occupational health physicians and workers with hepatitis.
- Analyzed data from 130,092 workers to determine the prevalence of HBV and HCV infections.
- Assessed the types of work, exacerbation rates, and perceived causes of exacerbation.
Main Results:
- Occupational health physicians identified 0.82% of workers with HBV and 0.48% with HCV.
- Around 30% of infected workers engaged in hazardous work, comparable to the general workforce.
- Approximately 30% of physicians and 22% of workers reported hepatitis exacerbations, with workers expressing concern about work-related causes.
Conclusions:
- Workers with hepatitis have significant concerns about the link between their work and disease exacerbation.
- While hazardous work prevalence is similar, perceived work-related causes and actual exacerbations highlight a need for workplace support and awareness.
- Further research is needed to elucidate the specific work-related factors contributing to hepatitis exacerbation.
Abstract:
Around three million Japanese are persistently infected with HBV or HCV. Though most of them work in various industries, little is known about the actual conditions in their workplaces. To clarify the workplace conditions of workers with hepatitis, three kinds of questionnaire surveys, answered by occupational health physicians and workers with hepatitis, were carried out. The rates of workers recognized as workers with hepatitis B or C by occupational health physicians were 0.82% and 0.48% of 130,092 workers, respectively. About 30% of workers with hepatitis were engaged in "hazardous work". The percentage of workers engaged in various types of hazardous work among workers with hepatitis was nearly the same as that among all Japanese workers. About 30% of occupational health physicians witnessed exacerbation of hepatitis in the workers at their workplaces, and 22% of workers with hepatitis experienced exacerbation of hepatitis. The rate of workers with hepatitis who had experienced exacerbation was not significantly different between workers with and without hazardous work. Workers with hepatitis have strong concerns about the relationship between work and exacerbation. As causes of exacerbation, occupational health physicians cited "unknown", "drinking" and "quit treatment" while workers with hepatitis answered "work-related causes", besides "unknown" and "drinking."
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