Related Experiment Video

Updated: Jul 16, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration
11:13

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Significant impact of survivin on myeloma cell growth

M Romagnoli1, V Trichet, C David

  • 11INSERM, UMR 601, 9 quai Moncousu, Nantes, F-44093, France.

Leukemia
|February 23, 2007
PubMed

Insights

Survivin, a key protein in cell death and division, is overexpressed in multiple myeloma (MM). Targeting survivin may offer a new therapeutic strategy for MM by inhibiting cancer cell growth and sensitizing cells to existing treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Survivin is an inhibitor of apoptosis protein (IAP) family member.
  • Survivin plays critical roles in mitosis and apoptosis.
  • Multiple myeloma (MM) is a plasma cell malignancy with poor outcomes.

Purpose of the Study:

  • To investigate survivin expression in myeloma cells.
  • To determine the role of survivin in multiple myeloma biology.
  • To evaluate survivin as a potential therapeutic target in MM.

Main Methods:

  • Analysis of survivin expression in myeloma cells.
  • Correlation of survivin protein levels with clinical MM course.
  • Survivin knockdown using RNA interference (RNAi).
  • Assessment of myeloma cell growth, apoptosis, and cell cycle.
  • Evaluation of myeloma cell sensitization to anti-myeloma agents.

Main Results:

  • Survivin is significantly overexpressed in myeloma cells.
  • Higher survivin expression correlates with a worse clinical course in MM.
  • Survivin knockdown inhibited myeloma cell growth by inducing apoptosis and disrupting the cell cycle.
  • Survivin knockdown sensitized myeloma cells to conventional anti-myeloma drugs.

Conclusions:

  • Survivin is a promising therapeutic target for multiple myeloma.
  • Targeting survivin may enhance the efficacy of existing MM treatments.
  • Further evaluation of survivin antagonists in MM treatment is warranted.

More Related Videos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity04:20

Knockdown of FAM83A to Verify Its Role in Cervical Cancer Cell Growth and Cisplatin Sensitivity

Published on: February 9, 2024

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...