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Updated: Jul 16, 2026
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
Published on: May 19, 2015
Sex specificity of ventral anterior cingulate cortex suppression during a cognitive task
Tracy Butler1, Julianne Imperato-McGinley, Hong Pan
1Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA. tab2006@med.cornell.edu
None:
Ventral anterior cingulate cortex (vACC) is a highly interconnected brain region considered to reflect the sometimes competing demands of cognition and emotion. A reciprocal relationship between vACC and dorsal ACC (dACC) may play a role in maintaining this balance between cognitive and emotional processing. Using functional MRI in association with a cognitively-demanding visuospatial task (mental rotation), we found that only women demonstrated vACC suppression and inverse functional connectivity with dACC. Sex differences in vACC functioning--previously described under conditions of negative emotion--are extended here to cognition. Consideration of participant sex is essential to understanding the role of vACC in cognitive and emotional processing.
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