Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioids and Down's syndrome.

Federica Mafrica1, Vincenzo Fodale

  • 1Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, School of Medicine, Policlinico Universitario "G Martino," Italy.

Journal of Opioid Management
|February 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Lack of the Nlrp3 inflammasome improves mice recovery following traumatic brain injury.

Frontiers in pharmacology·2025
Same author

Oxidative Stress Monitoring Platform: A Longitudinal In vitro Multinuclear (<sup>1</sup>H/<sup>19</sup>F) MR Spectroscopic Study.

Cell biochemistry and biophysics·2024
Same author

The dramatic increase in sudden cardiac deaths and the alarming low survival: A global call to action to improve outcome with the engagement of tertiary education system.

Journal of education and health promotion·2023
Same author

Medical simulation in pharmacology learning and retention: A comparison study with traditional teaching in undergraduate medical students.

Pharmacology research & perspectives·2019
Same author

A Novel Diagnostic and Prognostic Tool for Simple Decompression of Ulnar Nerve in Cubital Tunnel Syndrome.

World neurosurgery·2018
Same author

Lack of the Nlrp3 Inflammasome Improves Mice Recovery Following Traumatic Brain Injury.

Frontiers in pharmacology·2017

Opioid effects are influenced by how the body processes them and by specific receptors. Patients with Down's syndrome may have altered opioid receptors, impacting their pain perception and treatment.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Genetics

Background:

  • Opioids are crucial for pain management, sedation, and anesthesia.
  • Opioid efficacy relies on pharmacokinetic and pharmacodynamic properties, including metabolism and receptor interactions.
  • Down's syndrome is associated with neurobiological alterations, including potential changes in neurotransmission.

Purpose of the Study:

  • To explore the potential alterations in opioid receptors in patients with Down's syndrome.
  • To understand how these neurobiological differences may affect opioid pharmacodynamics and pharmacogenomics.
  • To highlight the importance of this knowledge for perioperative management.

Main Methods:

  • Review of existing literature on opioid metabolism, receptor binding, and neurobiology of Down's syndrome.

Related Experiment Videos

  • Analysis of studies reporting opioid concentrations in Down's syndrome patients.
  • Correlation of neurochemical findings with clinical manifestations like altered nociception.

    • Main Results:

    • Opioid biotransformation primarily occurs in the liver via oxidation, affecting drug distribution and duration.
    • Mu, delta, and kappa opioid receptors in the central nervous system interact with G proteins.
    • Evidence suggests altered opioid concentrations and potential structural/functional changes in opioid receptors in Down's syndrome.

    Conclusions:

    • Down's syndrome patients may exhibit unique responses to opioids due to receptor alterations.
    • Understanding these neurobiological differences is critical for optimizing pain management and perioperative care.
    • Further research is needed to fully elucidate opioid receptor function in Down's syndrome.