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[Antilysozyme activity of microorganisms causing acute and chronic pyelonephritis]

D Ch Urazbaeva, B A Ramazanova, B U Shalekenov

    Urologiia (Moscow, Russia : 1999)
    |February 24, 2007
    PubMed

    Insights

    Gram-negative bacteria in urine, particularly in pyelonephritis patients, exhibit high antilysozyme activity. This suggests their significant potential to persist and cause ongoing infectious-inflammatory processes.

    Area of Science:

    • Microbiology
    • Urology
    • Infectious Diseases

    Background:

    • Pyelonephritis, a kidney infection, involves complex bacterial interactions.
    • Understanding the etiological structure of urine microflora is crucial for treatment.
    • Bacterial persistence contributes to recurrent and chronic infections.

    Purpose of the Study:

    • To investigate the etiological structure of urine microflora in pyelonephritis patients.
    • To assess the antilysozyme activity of dominant bacterial strains.
    • To correlate bacterial antilysozyme activity with infectious-inflammatory process persistence.

    Main Methods:

    • Analysis of urine microflora in patients with acute and chronic pyelonephritis.
    • Isolation and identification of bacterial strains.
    • Measurement of bacterial antilysozyme activity for 175 strains.
    • Assessment of bacterial persistence potential.

    Main Results:

    • Gram-negative microorganisms were the predominant flora in urine samples.
    • A significant proportion of the studied bacterial strains exhibited high antilysozyme activity.
    • High antilysozyme activity was detected in bacteria isolated from patients with persistent infections.

    Conclusions:

    • The dominance of Gram-negative bacteria in pyelonephritis is confirmed.
    • High antilysozyme activity is a key factor enabling bacterial persistence in the urinary tract.
    • This finding highlights a potential therapeutic target for managing chronic and recurrent pyelonephritis.

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