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Updated: Jul 16, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions

Published on: January 26, 2024

A model of interdomain mobility in a multidomain protein

Yaroslav E Ryabov1, David Fushman

  • 1Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland 20742, USA.

Journal of the American Chemical Society
|February 27, 2007
PubMed
Summary

We developed a new NMR model to study protein domain mobility. This model characterizes the structural and dynamic properties of Lys48-linked diubiquitin, revealing domain reorientation crucial for biological function.

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