Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centromere dynamics.

Kerry Bloom1

  • 1Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. kerry_bloom@unc.edu

Current Opinion in Genetics & Development
|February 27, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coordinated chromosome motion emerges from mechanical coupling mediated by the physical spindle environment.

Molecular biology of the cell·2026
Same author

The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage.

International journal of molecular sciences·2025
Same author

Different relative scalings between transient forces and thermal fluctuations tune regimes of dynamic clustering.

Physical review. E·2025
Same author

The centromere bottlebrush requires a multi-microtubule attachment.

Molecular biology of the cell·2025
Same author

Centromeres are stress-induced fragile sites.

Current biology : CB·2025
Same author

Closing the loops: chromatin loop dynamics after DNA damage.

Nucleus (Austin, Tex.)·2024
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Centromere histone H3 (CenH3) is crucial for kinetochore assembly. Research is identifying histone chaperones that deposit CenH3 and regulate its localization, impacting chromosome dynamics during mitosis.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cell Biology

Background:

  • Eukaryotic kinetochores are built upon a specialized histone variant, centromere histone H3 (CenH3).
  • CenH3 forms a unique nucleosome that interfaces with microtubules, directing kinetochore assembly.
  • Pericentric chromatin exhibits elasticity, responding to microtubule dynamics during mitosis.

Purpose of the Study:

  • To identify histone chaperones responsible for CenH3 deposition at centromeric DNA.
  • To elucidate mechanisms restricting CenH3 localization to centromeres, preventing deposition on chromosome arms.
  • To understand the role of histone modifications in regulating distinct chromatin domains.

Main Methods:

  • Identification of histone chaperones involved in CenH3 deposition.

Related Experiment Videos

  • Investigation of mechanisms controlling CenH3 localization.
  • Analysis of histone modifications in pericentric and centromeric chromatin.

    • Main Results:

    • Progress is being made in identifying key histone chaperones for CenH3.
    • Mechanisms preventing CenH3 spread to chromosome arms are under investigation.
    • Histone modifications are implicated in regulating the distinct behaviors of centromeric and pericentric chromatin.

    Conclusions:

    • Understanding CenH3 deposition and localization is critical for kinetochore function.
    • The specialized nature of centromeric chromatin, regulated by CenH3 and its modifications, is essential for mitotic chromosome dynamics.
    • Further research into histone chaperones and modifications will illuminate kinetochore assembly and chromosome segregation.