Related Experiment Video
Updated: Jul 16, 2026

05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Methicillin-resistant Staphylococcus aureus infectious keratitis following refractive surgery
Renée Solomon1, Eric D Donnenfeld, Henry D Perry
1Ophthalmic Consultants of Long Island, Rockville Centre, New York 11570, USA.
American Journal of Ophthalmology
|February 27, 2007
Summary
Methicillin-resistant Staphylococcus aureus (MRSA) infectious keratitis is a serious complication following refractive surgery, particularly in healthcare workers. Early detection and treatment are crucial for visual recovery.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Surgical Complications
Background:
- Refractive surgery is a common procedure, but carries risks including infectious keratitis.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in healthcare-associated infections.
Observation:
- This study reviewed 13 cases of MRSA keratitis post-refractive surgery.
- Nine patients had healthcare or hospital exposure; some cases occurred without known exposure.
- Symptoms included decreased visual acuity, pain, and characteristic slit-lamp findings.
Findings:
- All cases were culture-proven MRSA keratitis.
- MRSA keratitis is an increasing complication, even in patients without direct healthcare exposure.
- This is the first case series on MRSA keratitis following refractive surgery, including LASIK enhancement and prophylaxis with fluoroquinolones.
Implications:
- Healthcare workers are at increased risk for MRSA keratitis after refractive surgery.
- Surgeons must be vigilant for community-acquired MRSA in post-refractive surgery patients.
- Prompt diagnosis, culturing, and appropriate antibiotic treatment are vital for visual outcomes.
Related Concept Videos
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
