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Related Experiment Videos

Second cycle: to hatch or not to hatch?

Molina B Dayal1, Anil Dubey, David Frankfurter

  • 1Fertility and IVF Center, George Washington University Medical Faculty Associates, Washington, DC 20037, USA. mdayal@mfa.gwu.edu

Fertility and Sterility
|February 27, 2007
PubMed
Summary
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Assisted hatching (AH) improves pregnancy outcomes for patients experiencing one prior failed in vitro fertilization (IVF) cycle. Subsequent IVF cycles benefit from AH, showing increased pregnancy, clinical pregnancy, and implantation rates.

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Embryology

Background:

  • Assisted hatching (AH) is a micromanipulation technique used in assisted reproductive technology.
  • Previous IVF cycles may result in implantation failure, necessitating further treatment strategies.

Purpose of the Study:

  • To evaluate the effectiveness of AH in improving pregnancy outcomes after a single failed fresh nondonor IVF cycle.
  • To determine the impact of AH on pregnancy rate (PR), clinical pregnancy rate (CPR), and implantation rate (IR).

Main Methods:

  • Retrospective analysis of IVF cycles.
  • Comparison of outcomes between patients who underwent AH and those who did not after a prior failed cycle.

Main Results:

Related Experiment Videos

  • Patients with one prior implantation failure demonstrated improved PR, CPR, and IR following AH in a subsequent IVF cycle.
  • AH was associated with significantly higher rates of successful implantation and pregnancy.

    • Conclusions:

    • Assisted hatching is a beneficial intervention for patients with a history of one failed IVF cycle.
    • Implementing AH can enhance reproductive success rates in subsequent IVF attempts.