Related Experiment Video
Updated: Jul 16, 2026

Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
Published on: May 16, 2021
Glutathione suppresses increase of serum creatine kinase in experimental hypoglycemia
Zhongli Jiang1, Masahiro Kohzuki, Taku Harada
1Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Abstract:
Inhibitory effects of reduced glutathione (GSH) on serum enzymes including alanine aminotransferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) were investigated in the hypoglycemic rabbits. Hypoglycemia lasting for 60 min was induced by intravenous injection of insulin (10U/kg) and then recovered by intravenous glucose injection. Serum levels of ALT, AST, LDH and CK increased significantly (p<0.05) at 6h after the induction of hypoglycemia. Plasma GSH, oxidized glutathione (GSSG) and total glutathione (TGSH) began to increase significantly (p<0.05) at 1h after the insulin injection, and GSSG/TGSH ratio rose significantly (p<0.05) at 6h after the induction of hypoglycemia. GSSG contents and GSSG/TGSH ratio in quadriceps significantly increased during hypoglycemia. Administration of GSH significantly decreased plasma GSSG levels, GSSG/TGSH ratio (p<0.05) and suppressed the rise of serum enzymes induced by hypoglycemia. These results suggest that GSH administration may play a preventive role for increases of serum enzymes by experimental hypoglycemia.
Related Concept Videos
Hypoglycemia and Glucagon
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are co-secreted in...
Dipeptidyl Peptidase 4 Inhibitors
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
