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Published on: June 8, 2014
Bisphosphonates and jaw osteonecrosis: the UAMS experience
Brett M Clarke1, Jennings Boyette, Emre Vural
1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Summary
Osteonecrosis of the jaw (ONJ) is a serious condition linked to bisphosphonate therapy. Increased awareness among healthcare providers is crucial for early detection and management of bisphosphonate-related ONJ.
Area of Science:
- Oncology
- Oral Surgery
- Pharmacology
Background:
- Osteonecrosis of the jaw (ONJ) is an emerging clinical concern, with numerous case reports and series published recently.
- The condition is not widely recognized within the head and neck surgery community.
Purpose of the Study:
- To investigate the characteristics and predisposing factors of osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonate therapy.
Main Methods:
- A retrospective chart review was conducted.
- 25 patients meeting inclusion criteria for ONJ were identified from 479 reviewed charts.
Main Results:
- The average patient age was 63.4 years, with 40% being female.
- Multiple myeloma was the most frequent comorbidity.
- Patients received bisphosphonates for an average of 4.4 years, with pamidronate being common. Concomitant steroid use and prior dental procedures were noted in a significant proportion of cases.
Conclusions:
- The findings underscore the necessity for heightened clinical awareness regarding the potential development of ONJ in patients undergoing bisphosphonate treatment.
- Early recognition and intervention are vital for managing bisphosphonate-related osteonecrosis of the jaw.
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