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Published on: September 6, 2017
Association of HLA-DQA1*03011-DQB1*0301 haplotype with the development of respiratory scleroma
Luis Alberto Sánchez-Marín1, Daniel Bross-Soriano, José Arrieta
1División clínica de Otorhinolaryngology, Hospital General Dr. Manuel Gea González, SSA, México, DF, México.
Objective:
Respiratory scleroma (RS) is a progressive, chronic, granulomatous disease caused by Klebsiella rhinoscleromatis. There is only one report of RS association with HLA-DQ3. In this study, molecular association of HLA class II and RS was determined.
Study Design And Setting:
Nine RS patients and 163 healthy controls were compared. DQA1, DQB1, and DRB1 loci were typed.
Results:
Statistical analysis demonstrated association between DQB1*0301 and susceptibility to RS (P(c) = 0.004). Haplotype analysis showed an association of DQA1*03011-DQB1*0301 (P = 1.21E-19) and DRB1*0407-DQA1*03011-DQB1*0301 (P = 0.0002).
Conclusions:
Results established that DQA1*03011-DQB1*0301 haplotype is a strong risk factor for development of RS.
