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Published on: February 26, 2013

Development of congestive heart failure in Japanese patients with atrial fibrillation

Taira Fukuda1, Takeshi Yamashita, Kouichi Sagara

  • 1Cardiovascular Institute Hospital, Tokyo, Japan. taira-f@mse.biglobe.ne.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|February 27, 2007
PubMed

Insights

Congestive heart failure (CHF) developed in 6.5% of Japanese atrial fibrillation (AF) patients over approximately 50 months. Structural heart disease was identified as the sole independent risk factor for CHF development in this AF population.

Area of Science:

  • Cardiology
  • Epidemiology
  • Internal Medicine

Background:

  • Atrial fibrillation (AF) and congestive heart failure (CHF) frequently coexist.
  • The temporal relationship between AF and CHF in Japanese patients remains unclear.

Purpose of the Study:

  • To investigate the incidence and risk factors for the development of CHF in Japanese patients with atrial fibrillation.
  • To clarify the temporal relationship between AF and CHF in this specific population.

Main Methods:

  • Prospective analysis of 248 Japanese AF patients without prior CHF history.
  • Follow-up period of approximately 50 months to monitor CHF development.
  • Cox-Hazard regression analysis to identify independent risk factors for CHF.

Main Results:

  • CHF requiring hospitalization developed in 6.5% of patients (2.0% per patient-year).
  • Structural heart disease and left ventricular hypertrophy were significantly associated with CHF development.
  • Structural heart disease was the only independent risk factor identified (HR 3.50).

Conclusions:

  • CHF develops at a rate of 2% per year in Japanese AF patients.
  • The presence of structural heart disease is the primary independent risk factor for CHF development in this population.
Abstract

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