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Urinary tissue factor levels in neoplastic diseases.

B A Lwaleed1, J L Francis, M Chisholm

  • 1University Department of Haematology, Southampton University Hospitals, Southampton, U.K.

Annals of Saudi Medicine
|February 27, 2007
PubMed
Summary
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Urinary tissue factor (uTF) levels are elevated in patients with malignant and inflammatory diseases compared to healthy individuals. Higher uTF indicates potential tumor progression and poorer patient survival.

Area of Science:

  • Oncology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Coagulation and fibrinolysis abnormalities are observed in cancer patients, with tissue factor (TF) playing a significant role.
  • Tumors and associated macrophages produce TF, increasing monocyte-derived TF (mTF).
  • Urinary TF (uTF) is present and may serve as a clinically relevant biomarker.

Purpose of the Study:

  • To investigate urinary tissue factor (uTF) levels in patients with various benign and malignant conditions.
  • To assess the correlation of uTF levels with disease status, tumor progression, and patient survival.

Main Methods:

  • A standardized kinetic chromogenic assay (KCA) was employed to measure uTF levels.
  • uTF was quantified in urine samples from healthy controls, patients with renal stones, and individuals with benign or malignant bladder, prostate, breast, and colorectal diseases.

Related Experiment Videos

  • Benign conditions were categorized as inflammatory or noninflammatory.

    • Main Results:

    • Elevated uTF levels were detected in patients with malignant and inflammatory diseases compared to controls and noninflammatory benign conditions (P<0.001 for bladder, breast, colorectum; P<0.01 for prostate).
    • Significantly higher uTF levels were observed in malignant bladder disease versus benign inflammatory bladder disease (P<0.05).
    • uTF levels correlated with tumor progression, patient survival, PSA levels, bone scan findings, and were higher in cases of bladder cancer recurrence and mortality.

    Conclusions:

    • Urinary tissue factor (uTF) levels are significantly elevated in malignant and inflammatory conditions.
    • Increased uTF is associated with tumor grade/stage, patient survival, and markers of tumor progression.
    • uTF shows potential as a biomarker for cancer detection and prognosis.