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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

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Interleukins in preeclampsia.

S O Olusi¹, M Diejomaoh, A Omu

¹Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Annals of Saudi Medicine

|February 27, 2007

Summary

Preeclampsia is linked to altered interleukin levels. Elevated interleukin-10 (IL-10) in preeclampsia may protect against maternal rejection.

Area of Science:

Obstetrics and Gynecology
Immunology
Reproductive Medicine

Background:

Preeclampsia is a complex pregnancy disorder with unknown causes, potentially involving endothelial damage.
Interleukins, key immune signaling molecules, are being investigated for their role in preeclampsia pathogenesis.

Purpose of the Study:

To investigate the association between maternal plasma concentrations of specific interleukins and preeclampsia.
To determine the role of interleukin-2 (IL-2), IL-2 receptor (IL-2R), IL-6, IL-8, and IL-10 in the etiology of preeclampsia.

Main Methods:

A case-control study involving 32 primigravidas with preeclampsia and 32 healthy pregnant controls.
Maternal plasma levels of IL-2, IL-2R, IL-6, IL-8, and IL-10 were measured at 32 weeks gestation using immunoassays.

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Isolation of Leukocytes from the Human Maternal-fetal Interface

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Published on: May 21, 2015

Main Results:

Maternal plasma IL-2 and IL-2R levels did not significantly differ between preeclampsia and normal pregnancy groups.
Significantly lower concentrations of IL-6 and IL-8 were observed in preeclampsia compared to normal pregnancy.
Maternal plasma IL-10 concentrations were significantly higher in women with preeclampsia than in normal pregnancy.

Conclusions:

Elevated maternal plasma IL-10 in preeclampsia may represent a protective mechanism against maternal immunorejection.
The study suggests a differential role for various interleukins in preeclampsia pathophysiology.