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13:41
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Human papillomavirus vaccine update.
1Department of Epidemiology and Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E6535, Baltimore, MD 21231, USA.
Current Infectious Disease Reports
|February 28, 2007
Summary
Two new prophylactic vaccines, Gardasil and Cervarix, are available for human papillomavirus (HPV) prevention. These vaccines are safe and effective against HPV types causing most cervical cancers, necessitating strategic implementation.
Area of Science:
- Immunology
- Oncology
- Public Health
Background:
- Two prophylactic vaccines, Gardasil and Cervarix, targeting human papillomavirus (HPV) are now available.
- HPV types 16 and 18 are responsible for approximately 70% of cervical cancers globally.
Purpose of the Study:
- To review the safety and efficacy of newly approved HPV vaccines.
- To discuss critical considerations for implementing HPV vaccination strategies.
- To explore the future of cervical cancer screening in the context of widespread vaccination.
Main Methods:
- Review of randomized controlled trials on Gardasil and Cervarix.
- Analysis of current public health recommendations and implementation challenges.
- Discussion of vaccination age, acceptance, and strategies for low-resource settings.
Main Results:
- Both Gardasil and Cervarix have demonstrated high safety and efficacy in preventing persistent HPV infections and lesions.
- Vaccines are particularly effective against HPV types 16 and 18.
Conclusions:
- The availability of effective HPV vaccines presents a significant opportunity for cervical cancer prevention.
- Strategic planning regarding vaccination age, acceptance, and accessibility is crucial for maximizing public health impact.
- The integration of HPV vaccination with cervical cancer screening protocols requires careful consideration.
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