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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
Toxicogenomics and ecotoxicogenomics for studying endocrine disruption and basic biology
Taisen Iguchi1, Hajime Watanabe, Yoshinao Katsu
1Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
General and Comparative Endocrinology
|February 28, 2007
Summary
Toxicogenomics and ecotoxicogenomics integrate genomics into toxicology to reveal how environmental chemicals impact wildlife, mice, and humans at a molecular level. These powerful tools advance our understanding of chemical toxicity and animal biology.
Area of Science:
- Environmental toxicology
- Genomics
- Molecular biology
Background:
- Environmental chemicals can disrupt endocrine systems in wildlife, mice, and humans.
- Understanding molecular mechanisms of chemical toxicity across species is crucial.
- Toxicogenomics and ecotoxicogenomics offer integrated approaches using genomics.
Purpose of the Study:
- To establish toxicogenomics/ecotoxicogenomics as powerful research tools.
- To investigate molecular mechanisms of chemical toxicity in various species.
- To study gene and protein expression in response to environmental toxicants.
Main Methods:
- Integration of genomics (transcriptomics, proteomics, metabolomics) into toxicology.
- Application of cDNA microarray technology.
- Development of a microarray system for Daphnia magna.
Main Results:
- Identification of estrogen-responsive genes and elements in the mouse reproductive tract.
- Elucidation of tributyltin's mechanisms via nuclear receptors (RXRα, PPARγ) using microarrays.
- Establishment of a functional microarray system for ecotoxicogenomic studies in Daphnia magna.
Conclusions:
- Toxicogenomics/ecotoxicogenomics are powerful tools for understanding chemical toxicity mechanisms.
- These approaches enhance the study of basic animal biology.
- Ecotoxicogenomics is vital for assessing environmental toxicant impacts on non-target organisms.
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