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Contrast material iodides: potential effects on radioactive iodine thyroid uptake.
A J Laurie1, S G Lyon, E C Lasser
1Department of Radiology, University of California, San Diego, School of Medicine, La Jolla 92093-0632.
Summary
Free iodide, a contaminant in intravenous contrast media, varies significantly but does not differ between ionic and nonionic types. These iodide levels may inhibit radioactive iodine uptake.
Area of Science:
- Radiochemistry
- Pharmacology
Background:
- Intravenous contrast media are widely used in medical imaging.
- Contaminants like free iodide and iodine in contrast media may affect diagnostic procedures.
- Radioactive iodine uptake is a critical parameter in certain medical assessments.
Purpose of the Study:
- To quantify free inorganic iodide and iodine levels in common intravenous contrast media.
- To investigate the potential role of these contaminants in radioactive iodine uptake inhibition.
Main Methods:
- Analysis of ionic and nonionic contrast media.
- Utilized a reduction-oxidation reaction with sodium nitrite for accurate quantification.
- Determined free iodine and free iodide concentrations.
Main Results:
- No free iodine was detected in any tested contrast media.
- Free iodide levels varied substantially, from 1.38 to 20.84 microgram/ml.
- No significant difference in free iodide levels was observed between ionic and nonionic contrast media.
Conclusions:
- Contaminant free iodide, present in varying amounts, is a key finding.
- The presence of free iodide in contrast media is implicated in short-term radioactive iodine uptake inhibition.
- Further research is warranted to fully elucidate the clinical implications.