Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody testing in peripheral neuropathies.

Steven Vernino1, Gil I Wolfe

  • 1Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9036, USA. steven.vernino@utsouthwestern.edu

Neurologic Clinics
|February 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Economic Evaluation of Thymectomy for the Treatment of Nonthymomatous Myasthenia Gravis.

JAMA network open·2026
Same author

Test-retest reliability of clinical supine-to-stand tests in patients with postural orthostatic tachycardia syndrome: A cautionary tale.

Heart rhythm·2026
Same author

Urinary dysfunction in myasthenia Gravis: a cross-sectional case-control study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Cutaneous Phosphorylated Alpha-Synuclein in Lewy Body Dementia.

Annals of clinical and translational neurology·2025
Same author

A wolf in synuclein clothing: Creutzfeldt-Jakob disease disguised as MSA.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2025
Same author

Ocular myasthenia gravis management.

Frontiers in neurology·2025
Same journal

Sports Neurology.

Neurologic clinics·2026
Same journal

Sports-Related Peripheral Nerve Injuries.

Neurologic clinics·2026
Same journal

Active Rehabilitation and Return to Play in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Autonomic Assessment and Management in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Management of Vestibular Symptoms in Sports-Related Concussion.

Neurologic clinics·2026
Same journal

Neuropsychological Assessment in Sport-Related Concussion: Evidence, Controversies, and Clinical Applications.

Neurologic clinics·2026
See all related articles

Autoantibody testing aids in diagnosing immune-mediated peripheral neuropathies, guiding potential immunomodulatory treatments. While debated, detecting specific autoantibodies like ganglioside or paraneoplastic antibodies can clarify neuropathy causes.

Area of Science:

  • Neurology
  • Immunology
  • Clinical Diagnostics

Background:

  • Peripheral neuropathies are often associated with autoantibodies, though their clinical utility is debated.
  • Serum autoantibodies targeting gangliosides or glycoproteins are linked to various sensory and motor neuropathy syndromes.
  • Paraneoplastic antibodies can identify neuropathies associated with underlying malignancies.

Purpose of the Study:

  • To explore the role and clinical significance of autoantibody testing in peripheral neuropathy diagnosis.
  • To evaluate the utility of detecting autoantibodies for identifying immune-mediated neuropathies.
  • To discuss the implications of autoantibody detection for guiding immunomodulatory therapy.

Main Methods:

  • Review of existing literature on autoantibodies in peripheral neuropathy.

Related Experiment Videos

  • Analysis of clinical cases where autoantibody testing influenced diagnosis and treatment.
  • Discussion of diagnostic criteria and therapeutic strategies based on antibody detection.

    • Main Results:

    • Autoantibodies are implicated in diverse peripheral neuropathy presentations.
    • Detection of specific autoantibodies can support an immune-mediated etiology.
    • Paraneoplastic antibodies are valuable markers for malignancy-associated neuropathies.

    Conclusions:

    • Autoantibody detection, within the appropriate clinical context, provides evidence for immune-mediated peripheral nerve disorders.
    • Identifying specific autoantibodies can inform the use of immunomodulatory therapies.
    • Further research is needed to refine the clinical application of autoantibody testing in neurology.