Related Experiment Video
Updated: Jul 16, 2026

08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase
Jennifer Nielsen Kahn1, Guillermo Garcia-Effron, Ming-Jo Hsu
1PHRI, Newark, NJ 07103, USA.
Antimicrobial Agents and Chemotherapy
|February 28, 2007
Abstract:
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655-->Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

