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Updated: Jul 16, 2026
11:28
Isolating Lymphocytes from the Mouse Small Intestinal Immune System
Published on: February 28, 2018
Enteropathy-type T-cell lymphoma after intestinal diffuse large B-cell lymphoma
Victor E Nava1, Philip Cohen, Michael Bishop
1Department of Pathology, Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC 20007, USA.
The American Journal of Surgical Pathology
|February 28, 2007
Summary
This is the first reported case of a patient developing enteropathy-type T-cell lymphoma (ETL) six years after being diagnosed with diffuse large B-cell lymphoma (DLBCL). Both rare lymphomas were successfully treated, with the patient remaining in remission.
Area of Science:
- Hematology
- Gastroenterology
- Oncology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Enteropathy-type T-cell lymphoma (ETL) is a rare intestinal lymphoma often associated with celiac disease.
Observation:
- A 47-year-old male with a history of DLBCL developed ETL six years later.
- The patient presented with gastrointestinal symptoms, and biopsies confirmed ETL.
- Concurrent diagnosis of celiac disease was made.
Findings:
- This case represents the first documented instance of metachronous DLBCL and ETL.
- Both lymphoma types were treated aggressively, leading to complete remission.
- The patient achieved remission after chemotherapy and allogeneic stem cell transplantation.
Implications:
- This case highlights the potential for developing different lymphoma types sequentially.
- Further research is needed to explore potential associations between DLBCL and ETL.
- Understanding these associations may improve diagnostic and therapeutic strategies for intestinal lymphomas.
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