Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Application of Integration: Problem Solving01:30

Application of Integration: Problem Solving

31
The process of breathing involves the periodic intake and expulsion of air, known as the respiratory cycle, which typically lasts about five seconds. Modeling the volume of air inhaled into the lungs as a function of time provides insight into both the dynamics and efficiency of pulmonary ventilation. This volume is determined by integrating the airflow rate over time, which captures the cumulative effect of air entering the lungs.Sinusoidal Model of AirflowAirflow during respiration is not...
31
Inhaled Medications01:23

Inhaled Medications

728
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
728
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

976
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
976
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen01:16

Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen

1.8K
Oxygen therapy is a pivotal aspect of medical care, particularly for patients with respiratory ailments. Two prominent oxygen-delivering systems include the Venturi mask and the transtracheal oxygen catheter.
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
1.8K
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

618
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
618
Oxygen Delivering System I: Nasal Cannula and Face Mask01:26

Oxygen Delivering System I: Nasal Cannula and Face Mask

1.4K
The human body requires oxygen to function, and when the natural process of respiration is hindered, external devices, including the following, are needed to help deliver this vital gas.
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>In vivo</i> lung microbiome alterations from burn pit emissions and/or sand inhalation exposures.

Frontiers in public health·2026
Same author

Revealing the global longline fleet with satellite radar.

Scientific reports·2022
Same author

Degenerate brainstem circuitry after combined physiochemical exposure to jet fuel and noise.

Journal of toxicology and environmental health. Part A·2021
Same author

Acute and two-week inhalation toxicity studies in rats for Polyalphaolefin (PAO) fluid.

Journal of toxicology and environmental health. Part A·2020
Same author

Illuminating dark fishing fleets in North Korea.

Science advances·2020
Same author

Toxicity and human health assessment of an alcohol-to-jet (ATJ) synthetic kerosene.

Journal of toxicology and environmental health. Part A·2020
Same journal

New Approach Methodologies (NAMs) for Carcinogenicity Evaluation.

Toxicologic pathology·2026
Same journal

2025 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: Pathology Working Groups (PWGs) in Toxicologic Pathology.

Toxicologic pathology·2026
Same journal

Toxicologic Pathology Forum*: Opportunities and Challenges in the Use of Artificial Intelligence in Nonclinical Toxicologic Histopathology Evaluations.

Toxicologic pathology·2026
Same journal

New Modalities and Carcinogenicity Assessment.

Toxicologic pathology·2026
Same journal

Second Joint Annual Congress of the British Society of Toxicologic Pathology and the European Society of Toxicologic Pathology Special Issue.

Toxicologic pathology·2026
Same journal

Hemangiosarcomas in Intercostal Brown Adipose Tissues of the Sternum Induced by Urethane in TgrasH2 Mice.

Toxicologic pathology·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
10:10

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface

Published on: February 23, 2020

7.5K

Inhalation exposure systems: design, methods and operation.

Brian A Wong1

  • 1CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA. bwong@ciit.org

Toxicologic Pathology
|February 28, 2007
PubMed
Summary
This summary is machine-generated.

Laboratory inhalation studies require controlling variables for accurate results. Engineering controls for animal environment, exposure atmosphere, and inhaled dose improve the study of biological responses.

More Related Videos

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
05:07

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

Published on: March 18, 2019

6.8K
Whole-Body Nanoparticle Aerosol Inhalation Exposures
10:11

Whole-Body Nanoparticle Aerosol Inhalation Exposures

Published on: May 7, 2013

16.2K

Related Experiment Videos

Last Updated: Jan 13, 2026

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
10:10

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface

Published on: February 23, 2020

7.5K
Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
05:07

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

Published on: March 18, 2019

6.8K
Whole-Body Nanoparticle Aerosol Inhalation Exposures
10:11

Whole-Body Nanoparticle Aerosol Inhalation Exposures

Published on: May 7, 2013

16.2K

Area of Science:

  • Toxicology
  • Respiratory Physiology
  • Environmental Health

Background:

  • The respiratory system is a primary entry route for inhaled substances, including pharmaceuticals and toxins.
  • Inhalation studies are crucial for assessing the effects of environmental, occupational, and medical exposures.
  • Variability in study conditions can significantly impact the reliability of inhalation study outcomes.

Purpose of the Study:

  • To identify key factors influencing inhalation study variability.
  • To highlight the role of engineering controls in managing these factors.
  • To enable reproducible assessment of animal biological responses in inhalation studies.

Main Methods:

  • Engineering environmental controls (temperature, humidity, gas content, noise).
  • Monitoring and adjusting exposure atmospheres for consistency.
  • Implementing respiration monitoring to control inhaled dose.
  • Selecting appropriate engineering techniques for study management.

Main Results:

  • Engineering controls effectively manage animal environment, exposure atmosphere, and inhaled dose.
  • Controlled variables enhance the reproducibility of biological response data.
  • Consistent exposure conditions are achievable through meticulous monitoring and engineering.

Conclusions:

  • Controlling environmental, atmospheric, and dose factors through engineering is essential for reliable inhalation studies.
  • Engineering solutions allow toxicologic pathologists to focus on the biological variability.
  • Optimized study conditions improve the scientific rigor and interpretability of inhalation research.