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Updated: Jul 16, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Current status of cerebral protection with mild-to-moderate hypothermia after traumatic brain injury
1Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, P.R.China. Jiangjyb@online.sh.cn
Purpose Of Review:
The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury.
Recent Findings:
More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in patients with severe traumatic brain injury. Long-term mild hypothermia may be useful for severe traumatic brain-injured patients.
Summary:
Mild-to-moderate hypothermia plays a significant role in cerebral protection after traumatic brain injury.
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