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Related Experiment Videos

Asteroid bodies in a lymph node aspirate. A case report.

Preetha Rajasekharan1, Swati Narurkar, Keyuri Patel

  • 1Department of Pathology, KJ Somaiya Medical College & Research Centre, Sion, Mumbai, India. dr_pnair@yahoo.co.in

Acta Cytologica
|March 3, 2007
PubMed
Summary

Asteroid bodies, a rare cytologic finding, can aid in the early diagnosis of sarcoidosis when identified in lymph node aspirates. This aids in differentiating sarcoidosis from other granulomatous conditions.

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Area of Science:

  • Cytopathology
  • Dermatology
  • Rheumatology

Background:

  • Sarcoidosis is a multisystem disease with diverse clinical presentations.
  • Cutaneous lesions occur in one-third of patients and may precede systemic disease.
  • Early diagnosis of sarcoidosis can be challenging.

Observation:

  • A 37-year-old woman presented with asymptomatic subcutaneous nodules and lymphadenopathy.
  • Epitrochlear lymph node aspirate revealed noncaseating epithelioid granulomas, multinucleate giant cells, and asteroid bodies.
  • Subcutaneous nodule biopsy confirmed the findings.

Findings:

  • The lymph node aspirate demonstrated characteristic features of sarcoidosis, including asteroid bodies.
  • Elevated erythrocyte sedimentation rate and angiotensin-converting enzyme levels supported the diagnosis.

Related Experiment Videos

  • Chest radiograph showed bilateral reticulonodular shadows.

    • Implications:

    • Asteroid bodies are a rare but significant cytologic finding in sarcoidosis.
    • Cytologic identification of asteroid bodies can facilitate early diagnosis.
    • Distinguishing sarcoidosis from other granulomatous lesions is crucial, especially with negative special stains.