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[Brugada syndrome unmasked by lithium treatment]
Raphael Sandras1, Francois Lesaffre, Jérome Lacotte
1Département de Cardiologie et Pathologies Vasculaires, CHU, Reims. sandras.r@wanadoo.fr
Introduction:
The Brugada syndrome is a rare genetic disease that can lead to death. Its diagnosis requires electrocardiography.
Case:
A 36-year-old man was admitted with syncope. Brugada syndrome was diagnosed by the typical ECG pattern. The interaction between lithium therapy and ECG was shown clearly by the alternating type 1 and type 3 Brugada ECG patterns, depending on lithium status.
Discussion:
The Brugada syndrome may be unmasked by lithium therapy, due to its properties as a Na+ channel blocker, even at low doses. This case also demonstrated the usefulness of ECG in detecting the Brugada syndrome before and during lithium prescription.
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