Related Experiment Video
Updated: Jul 16, 2026
Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology
Published on: March 24, 2015
Label-free biosensor: a novel phage-modified Light Addressable Potentiometric Sensor system for cancer cell
Yunfang Jia1, Ming Qin, Hongkai Zhang
1Department of Microelectronics, Nankai University, Tianjin 300071, China. xzfeng@nankai.edu.cn
Abstract:
Early diagnosis has become the most important factor influencing the cancer's curing efficiency in clinical medicine. Here we present a new way for detection of cancer markers and cancer cells based on phage-modified Light Addressable Potentiometric Sensor (phage-LAPS). Phages were immobilized on the Si(3)N(4) chip surfaces covalently. Using the back-illuminating system, this phage-LAPS is tested to detect human phosphatase of regenerating liver-3 (hPRL-3) in the concentrations of 0.04-400 nM, and the mammary adenocarcinoma cell (MDAMB231) in the concentrations of 0-105 mL. The maximum responding signal is about 10 and 60 microV, respectively. The results demonstrated that the system was more applicable to detection of cancer cell than that of cancer biomarkers. This work might show potential application in clinic assays of cancer and the study of phage-cell interaction.
More Related Videos
08:22Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
09:55All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
Published on: December 20, 2021
