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Published on: March 30, 2019
Metronomic chemotherapy: an antiangiogenic scheduling
B Laquente1, F Viñals, J R Germà
1Laboratori de Recerca Translacional, Institut Català d'Oncologia-IDIBELL, L'Hospitalet de Llobregat, Spain.
Summary
Metronomic chemotherapy, a novel cancer treatment, uses frequent low doses of chemotherapy drugs to inhibit tumor blood vessel growth (angiogenesis). This approach offers reduced toxicity and a lower risk of drug resistance compared to traditional methods.
Area of Science:
- Oncology
- Pharmacology
- Cancer Biology
Background:
- Conventional chemotherapy targets rapidly dividing tumor cells.
- Emerging research explores using chemotherapy drugs as anti-angiogenic agents.
- Tumor angiogenesis, crucial for tumor growth, involves endothelial cell division.
Purpose of the Study:
- To review the anti-angiogenic potential of chemotherapy drugs.
- To explore the strategy of metronomic chemotherapy.
- To summarize experimental and clinical evidence for metronomic chemotherapy.
Main Methods:
- Review of experimental studies on metronomic chemotherapy.
- Analysis of clinical trial data for metronomic chemotherapy.
- Examination of the rationale behind targeting angiogenesis with chemotherapy.
Main Results:
- Metronomic chemotherapy involves chronic, low-dose drug administration at regular intervals.
- This schedule enhances the anti-angiogenic activity of certain cytotoxic agents.
- Metronomic chemotherapy demonstrates lower toxicity and reduced risk of drug resistance.
Conclusions:
- Metronomic chemotherapy is a promising strategy for cancer treatment.
- It leverages cytotoxic drugs for their anti-angiogenic effects.
- This approach offers a potentially less toxic and more effective treatment schedule.
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