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Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Bithiazole metabolites from the myxobacterium Myxococcus fulvus
Jong-Woong Ahn1, Kyoung Hwa Jang, Hyeong-Cheol Yang
1Division of Marine Environment & Bioscience, College of Ocean Science and Technology, Korea Maritime University, Youngdo, Busan, Korea.
Abstract:
Two new bithiazole metabolites (3, 4) along with the previously reported compounds (1, 2) were isolated from the culture broth of the gliding bacterium Myxococcus fulvus collected from a Korean soil. The structures of these compounds were determined to be analogous to myxothiazole A on the basis of combined spectroscopic analyses. The new compounds exhibited significant cytotoxicity and moderate antifungal activity against the mouse fibloblast cell-line L929 and Candida albicans, respectively. These data were consistent with the previous finding that the bioactivity of myxothiazoles was highly dependent on the presence of terminal methoxy enol functionality.
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