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[Pathogenesis of syringomyelia].
Edward Zderkiewicz1, Robert Kaczmarczyk
1Katedra i Klinika Neurochirurgii i Neurochirurgii Dzieciêcej, Akademia Medyczna w Lublinie, Lublin.
Neurologia I Neurochirurgia Polska
|March 3, 2007
Summary
Syringomyelia may stem from known causes or idiopathic pathways. Impaired spinal cord extracellular fluid outflow, potentially via Virchow-Robin spaces, may cause syringomyelic cavity formation.
Area of Science:
- Neurology
- Pathophysiology
- Spinal Cord Disorders
Context:
- Syringomyelia involves cavity formation within the spinal cord.
- Idiopathic syringomyelia's pathogenesis remains unclear.
- Known causes include tumors, inflammation, trauma, and craniovertebral malformations.
Purpose:
- To review historical hypotheses on syringomyelia etiology and pathophysiology.
- To critically discuss existing theories.
- To propose a mechanism for idiopathic syringomyelia.
Summary:
- Syringomyelic cavities can result from various pathological processes.
- The paper emphasizes the role of extracellular and subarachnoid space communication.
- Disturbed extracellular fluid outflow in the spinal cord may lead to cavity dilatation.
Impact:
- Provides a historical perspective on syringomyelia research.
- Highlights the potential significance of perivascular spaces in syringomyelia.
- Suggests a novel pathophysiological mechanism for idiopathic syringomyelia.
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