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Ibuprofen does not affect serum electrolyte concentrations after an ultradistance run
Charles L Dumke1, David C Nieman, Kevin Oley
1Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA. dumkecl@appstate.edu
British Journal of Sports Medicine
|March 3, 2007
Summary
Ibuprofen did not affect serum electrolytes in ultrarunners. The extreme stress of 160 km running caused significant changes in hydration and muscle damage markers.
Area of Science:
- Sports Medicine
- Exercise Physiology
- Biochemistry
Background:
- Ultradistance running events, such as 160 km trail races, place significant physiological stress on athletes.
- Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are commonly used by athletes, but their effects on physiological markers during extreme exertion are not fully understood.
Purpose of the Study:
- To investigate the impact of ibuprofen on serum electrolyte concentrations in athletes participating in a 160 km running race.
- To assess changes in various serum biochemical markers in response to ultradistance running.
Main Methods:
- A cohort of 29 runners ingested ibuprofen (600 mg pre-race, 1200 mg during), while 25 controls abstained.
- Blood samples were collected before and immediately after the 160 km race.
- Serum electrolyte and biochemical profiles were analyzed, with statistical significance determined using a general linear model with repeated measures.
Main Results:
- Ibuprofen ingestion did not significantly alter serum electrolyte concentrations or creatine kinase levels.
- The race itself caused significant decreases in serum sodium, potassium, chloride, and calcium.
- Significant increases were observed in creatine kinase, creatinine, blood urea nitrogen, uric acid, and glucose post-race.
Conclusions:
- Ibuprofen does not appear to affect serum electrolyte concentrations during ultradistance running.
- The physiological stress of ultradistance running leads to notable alterations in specific serum markers, independent of ibuprofen use.
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