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Updated: Jul 16, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

PARC and CUL7 form atypical cullin RING ligase complexes.

Jeffrey R Skaar1, Laurence Florens, Takeya Tsutsumi

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Cancer Research
|March 3, 2007
PubMed
Summary

The study reveals that PARC, a protein related to PARKin, forms distinct complexes with CUL7, influencing ubiquitin ligase activity. These PARC- and CUL7-containing complexes are regulated, with multiple subcomplexes showing E3 ubiquitin ligase activity.

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