Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Inflammation01:38

Inflammation

Overview
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-density lipoprotein cholesterol: function, dysfunction, and clinical implications.

American journal of preventive cardiology·2026
Same author

Soluble Immune Checkpoint Protein and Lipid Network Associations with All-Cause Mortality Risk: Trans-Omics for Precision Medicine (TOPMed) Program.

medRxiv : the preprint server for health sciences·2025
Same author

Higher HDL cholesterol levels are associated with increased markers of interstitial myocardial fibrosis in the MultiEthnic Study of Atherosclerosis (MESA).

Scientific reports·2023
Same author

Higher HDL Cholesterol Levels Are Associated with Increased Markers of Interstitial Myocardial Fibrosis: Insights from The Multi-Ethnic Study of Atherosclerosis.

Research square·2023
Same author

Assessment of respiratory support decision and the outcome of invasive mechanical ventilation in severe COVID-19 with ARDS.

Journal of intensive medicine·2023
Same author

Dystrophic Epidermolysis Bullosa Pruriginosa: Successfully Treated With Dupilumab.

Dermatitis : contact, atopic, occupational, drug·2023

Related Experiment Video

Updated: Jul 16, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

Chronic intermittent hypoxia induces atherosclerosis.

Vladimir Savransky1, Ashika Nanayakkara, Jianguo Li

  • 1Division of Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.

American Journal of Respiratory and Critical Care Medicine
|March 3, 2007
PubMed
Summary

Chronic intermittent hypoxia (CIH) combined with a high-cholesterol diet induces atherosclerosis in mice. This study establishes a link between CIH, dyslipidemia, and the development of atherosclerotic lesions.

Related Experiment Videos

Last Updated: Jul 16, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

Area of Science:

  • Cardiovascular Research
  • Sleep Medicine
  • Metabolic Disorders

Background:

  • Obstructive sleep apnea is linked to hyperlipidemia, atherosclerosis, and cardiovascular risk.
  • A direct causal relationship between obstructive sleep apnea and atherosclerosis remains unproven.

Purpose of the Study:

  • To investigate if chronic intermittent hypoxia (CIH) can induce atherosclerosis.
  • To examine the role of CIH in the development of atherosclerotic lesions in a mouse model.

Main Methods:

  • Male C57BL/6J mice were fed either a high-cholesterol or regular diet.
  • Mice were exposed to either CIH or intermittent air (control) for 12 weeks.

Main Results:

  • Mice on a high-cholesterol diet exposed to CIH developed atherosclerotic lesions.
  • No atherosclerosis was observed in mice on a high-cholesterol diet with normal air or mice on a regular diet with CIH.
  • CIH exacerbated diet-induced dyslipidemia, increasing lipid peroxidation and altering hepatic lipoprotein secretion.

Conclusions:

  • Chronic intermittent hypoxia promotes atherosclerosis development.
  • Diet-induced dyslipidemia is a critical factor in CIH-induced atherosclerosis.