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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
A required course in human genomics, pharmacogenomics, and bioinformatics
Daniel A Brazeau1, Gayle A Brazeau
1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, NY, USA. dbrazeau@buffalo.edu
This course enhanced pharmacy students' understanding of human genetics and genomics in drug therapy. Students gained knowledge in pharmacogenetics, from basic principles to applications in optimizing patient care and drug selection.
Area of Science:
- Genetics
- Genomics
- Bioinformatics
- Pharmacology
Background:
- Human genetics and genomics are increasingly vital in modern medicine.
- Understanding these fields is crucial for optimizing drug therapy and patient care.
- Pharmacogenomics integrates genetics and pharmacology to tailor drug treatments.
Purpose of the Study:
- To educate PharmD students on the principles and applications of human genetics and genomics.
- To cover pharmacogenomics, bioinformatics, and their role in drug therapy optimization.
- To enhance student understanding of genetic influences on drug response for improved patient care and counseling.
Main Methods:
- A 2-credit hour course, "Principles of the Human Genome, Pharmacogenomics, and Bioinformatics," was implemented.
- Third-professional year PharmD students were the target audience.
- Student learning was assessed via written examinations, in-class exercises, and literature-based papers.
Main Results:
- Student course ratings for pedagogical format and relevance to professional practice showed significant improvement.
- The course successfully conveyed complex topics in human genetics and genomics.
- Students demonstrated an enhanced understanding of pharmacogenetics and its clinical applications.
Conclusions:
- The course effectively provided pharmacy students with a comprehensive understanding of pharmacogenetics.
- It covered the spectrum from genetic principles to specific pharmacogenomic applications in drug therapy.
- The curriculum is relevant and beneficial for future pharmacists in optimizing patient care.
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