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Updated: Jul 16, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Differentiating bipolar disorder from depression in primary care
David J Muzina1, Elisa Colangelo, J Sloan Manning
1Bipolar Disorders Research Unit, Department of Psychiatry and Psychology, Cleveland Clinic, OH 44195, USA. muzinad@ccf.org
Abstract:
Because patients with bipolar disorder spend more time in the depressed phase than in the manic phase, many receive an incorrect diagnosis of unipolar major depression and receive inadequate or improper treatment for it, leading to a dramatically increased risk of morbidity and suicide. Greater diagnostic accuracy is needed.
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