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Do hydronephrosis and extracorporeal shock wave lithotripsy affect carbohydrate antigens?
Turgay Akgül1, Bariş Nuhoğlu, Ali Ayyildiz
1Second Urology Clinic, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. turgayakgul@gmail.com
International Urology and Nephrology
|March 6, 2007
Summary
Serum levels of carbohydrate antigen 19-9 (CA 19-9) and carbohydrate antigen 125 (CA 125) were significantly elevated in patients with hydronephrosis and renal stones. Extracorporeal shock wave lithotripsy (ESWL) did not affect these tumor marker levels.
Area of Science:
- Urology
- Nephrology
- Oncology
Background:
- Hydronephrosis and renal stones can impact various physiological markers.
- Carbohydrate antigens (CA 19-9, CA 15-3, CA 125) are sometimes associated with renal conditions.
- Understanding these markers' behavior is crucial for patient management.
Purpose of the Study:
- To evaluate serum levels of CA 19-9, CA 15-3, and CA 125 in patients with hydronephrosis and renal stones.
- To determine the effect of Extracorporeal Shock Wave Lithotripsy (ESWL) on these antigen levels.
Main Methods:
- Prospective study comparing 30 patients with hydronephrosis/renal stones to 20 healthy controls.
- Serum samples collected pre- and post-ESWL.
- Electro-immunoassay method used to measure CA 19-9, CA 15-3, and CA 125.
Main Results:
- CA 19-9 and CA 125 levels were significantly higher in patients compared to controls.
- CA 15-3 levels did not show a significant difference between groups.
- No statistically significant changes in CA 19-9, CA 15-3, or CA 125 were observed after ESWL.
Conclusions:
- Elevated serum CA 19-9 and CA 125 are associated with hydronephrosis and renal stones.
- ESWL treatment does not appear to alter serum levels of these carbohydrate antigens.
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