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Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Radical induced fragmentation of amino acid esters using triphenylcorrole(CuIII) complexes
Chagit Denekamp1, Emilia Rabkin
1Department of Chemistry and Institute of Catalysis Science and Technology, Technion - Israel Institute of Technology, Haifa, Israel. chchagit@tx.technion.ac.il
Abstract:
A triphenylcorrole(CuIII) complex is covalently bound to amino acid esters at the nitrogen atom. As a result radical anions are generated, inducing the occurrence of side-chain reactions under CID conditions. Almost all of the amino acid esters that were studied show abundant ions that correspond to fragmentation at the alpha carbon either with or without the loss of the alkoxy ester moiety. Distinctive CID spectra were also recorded for leucine and isoleucine complexes. Initial results with short peptides are also shown.
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