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The antiphospholipid syndrome.

Michael J Fischer1, Joyce Rauch, Jerrold S Levine

  • 1Department of Medicine, Section of Nephrology, University of Illinois at Chicago, Chicago, IL, USA.

Seminars in Nephrology
|March 6, 2007
PubMed
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Antiphospholipid syndrome (APS) is an autoimmune disorder causing blood clots. This review covers APS, its kidney manifestations, and current treatment strategies for this hypercoagulable condition.

Area of Science:

  • Autoimmune disorders
  • Hematology
  • Nephrology

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune condition linked to antiphospholipid autoantibodies (aPL).
  • It causes hypercoagulability, affecting blood vessels of all sizes, leading to thrombosis, embolism, or thrombotic microangiopathy.
  • APS can impact virtually any organ, with significant renal involvement being a key concern.

Purpose of the Study:

  • To review the fundamental principles of APS.
  • To discuss recent advancements in understanding APS.
  • To explore the spectrum of renal diseases associated with APS and its impact on pre-existing kidney conditions.

Main Methods:

  • Literature review of basic principles and recent advances in APS.
  • Analysis of clinical associations between aPL and hypercoagulability.

Related Experiment Videos

  • Examination of reported renal manifestations in APS patients.

    • Main Results:

    • APS involves aPL and hypercoagulability, affecting diverse blood vessels and organs.
    • Renal involvement in APS presents a broad spectrum of diseases.
    • APS can exacerbate pre-existing renal conditions.

    Conclusions:

    • Understanding APS pathophysiology is crucial for managing its systemic and renal complications.
    • Further research into APS pathogenesis and its renal impact is warranted.
    • Current treatment recommendations for APS should be considered for affected patients, particularly those with kidney disease.