Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal death: where does the end begin?

Laura Conforti1, Robert Adalbert, Michael P Coleman

  • 1The Babraham Institute, Babraham, Cambridge CB22 3AT, UK.

Trends in Neurosciences
|March 7, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KCa3.1 channels regulate the tumor infiltration of functionally competent NK cells in head and neck cancer.

Scientific reports·2025
Same author

Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer.

bioRxiv : the preprint server for biology·2025
Same author

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides.

Neurobiology of disease·2025
Same author

Chronically Low NMNAT2 Expression Causes Sub-lethal SARM1 Activation and Altered Response to Nicotinamide Riboside in Axons.

Molecular neurobiology·2024
Same author

Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production.

Nature communications·2024
Same author

NMNAT2 is a druggable target to drive neuronal NAD production.

Nature communications·2024
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
Same journal

Exercise as a regulator of glymphatic function.

Trends in neurosciences·2026
See all related articles

Understanding neurodegenerative disorders like Alzheimer's and Parkinson's is complex. Researchers are exploring new methods to determine the sequence of cellular events and their causes in these devastating diseases.

Area of Science:

  • Neurobiology
  • Cellular Biology
  • Neurology

Background:

  • Neurodegenerative diseases involve the progressive loss of neurons.
  • Interconnectedness of neuronal compartments complicates understanding degeneration sequences.
  • Molecular defects can cause widespread neuronal damage.

Purpose of the Study:

  • To review novel approaches for studying neurodegeneration.
  • To investigate the spatiotemporal sequence of events in neurodegenerative disorders.
  • To explore causal relationships in neuronal degeneration.

Main Methods:

  • Review of novel research methodologies.
  • Analysis of studies on amyotrophic lateral sclerosis, spinal muscular atrophy, glaucoma, Alzheimer's disease, Parkinson's disease, and polyglutamine disorders.

Related Experiment Videos

  • Examination of cellular and molecular mechanisms of neurodegeneration.

    • Main Results:

    • Current understanding of the initial events in neurodegeneration is incomplete.
    • The precise sequence and causes of neuronal compartment degeneration remain debated.
    • Significant controversy exists regarding the primary sites of degeneration.

    Conclusions:

    • Novel approaches are crucial for unraveling complex neurodegenerative processes.
    • Further research is needed to resolve fundamental questions about what degenerates first and why.
    • Strategies for future research are proposed to address current controversies.