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Updated: Jul 16, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Cutaneous vascular alterations in psoriatic patients treated with cyclosporine
Giuseppe Stinco1, Stefano Lautieri, Francesca Valent
1Institute of Dermatology, Department of Clinical and Experimental Pathology and Medicine, University of Udine School of Medicine, Udine, Italy. giuseppe.stinco@uniud.it
Abstract:
Videocapillaroscopy can be used to assess cutaneous microcirculation modifications in vivo, and therefore allows assessment of variations in the microvascular architecture in psoriatic subjects during treatment. The aim of this study was to observe and quantify the modifications of the superficial capillary bed in psoriatic plaques during treatment with cyclosporin A. Twelve patients with psoriasis vulgaris were treated with an initial dose of 4 mg/kg/day cyclosporin A over a period of 3 months with periodic clinical and capillaroscopic assessments. Clinical resolution of the lesions and a reduction in microcirculatory alterations was observed in 70% of patients, although none returned to a normal capillaroscopic pattern.
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